Life Kaley Cuoco gives shoutout to ‘inspiring’ ‘Big Bang’ audience member with rare skin disease April 26, 2019 Hannah Yasharoff, USA TODAY Comments Off on Kaley Cuoco gives shoutout to ‘inspiring’ ‘Big Bang’ audience member with rare skin disease As "The Big Bang Theory" approaches its May 16 series finale, Kaley Cuoco is taking time to thank a fan who has inspired her all season long.